Database : HANSEN Search on : LINFOCITOS T/METAB [Subject descriptor] References found : 6 [refine] Displaying: 1 .. 6   in format [Detailed]

page 1 de 1

1 / 6

HANSEN

select to print

Id: 13450 Author: Modlin, Robert L; Hofman, Florence M; Horwitz, David A; Husmann, Linda A; Gillis, Steven; Taylor, Clive R; Rea, Thomas H Title: In situ identification of cells in human leprosy granulomas with monoclonal antibodies to interleukin 2 and its receptor ..- Source: s.l; s.n; Jun. 1984. 6 p. ilus, tab, graf. Abstract: Leprosy is a chronic granulomatous disease with an immunologic spectrum in which lepromatous leprosy patients have defective cell-mediated immune responses, in comparison to tuberculoid leprosy patients. Immunoregulatory aspects of this spectrum were investigated by using monoclonal antibodies to interleukin 2 (IL 2), IL 2 receptors (Tac), and T lymphocyte subpopulations with immunoperoxidase techniques on frozen sections of skin biopsy specimens from 10 tuberculoid and 10 lepromatous patients. A comparison of IL 2+ cells revealed markedly fewer IL 2+ cells in lepromatous specimens (lep. 0.028% +/- 0.02 vs tub. 0.46% +/- 0.28, p less than 0.001). These IL 2+ cells were large, exhibited cytoplasmic staining, and on double immunostaining were Leu-4+, Leu-3a+, Leu-2a-, Tac-, and OKT6-, consistent with the fact they are IL 2 producers. Equivalent numbers of Tac+ cells were observed in both lepromatous and tuberculoid granulomas (lep. 1.5% +/- 0.5 vs tub. 2.1% +/- 0.7, p, NS), suggesting that the responder cells are present in both conditions. The tuberculoid granuloma was highly organized, composed of a central core of mature macrophages, Leu-3a+ and Tac+ cells with a surrounding mantle of Leu-2a+, Leu-3a+, IL 2+, Tac+, and OKT6+ cells. In lepromatous granulomas, Leu-2a+, Leu-3a+, Tac+, and rare IL 2+ cells were randomly admixed with bacilli-laden macrophages. The defective cell-mediated immune responses in lepromatous leprosy appears to be associated with diminished IL 2 production and disorganization of the granuloma.(AU). Descriptors: GRANULOMA/imunol GRANULOMA/metab HISTOCITOQUIMICA INTERLEUCINA-2/bios INTERLEUCINA-2/imunol HANSENIASE/imunol HANSENIASE/metab LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T/metab Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01415/s

2 / 6

HANSEN

select to print

Id: 10338 Author: Mesret, Yohannes; Reed, Allen H; Howe, Rawleigh Title: Proliferative responses of T cells from the skin and nerve lesions of leprosy patients ..- Source: s.l; s.n; 1995. 10 p. tab, graf. Descriptors: ANTIGENOS CD28 ANTIGENOS CD3 ANTIGENOS CD45 INTERFERON TIPO II RECEPTORES DA INTERLEUCINA 2 INTERLEUCINA-2 INTERLEUCINA-4 HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA TRANSFORMAÇAO LINFOCITICA MITOGENOS NERVOS PERIFÉRICOS FITOHEMAGLUTININAS PELE LINFOCITOS T LINFOCITOS T CELULAS CULTIVADAS Location: BR191.1; 07189/s

3 / 6

HANSEN

select to print

Id: 10301 Author: Thole, Jelle E. R; Janson, Anneke A. M; Cornelisse, Yolanthe; Schreuder, Geziena M. T; Wieles, Brigitte; Naafs, Ben; Vries, Rene R. P. de; Ottenhoff, Tom H. M Title: HLA-class II-associated control of antigen recognition by T cells in leprosy: a prominent role for the 30/31-kDa antigens ..- Source: s.l; s.n; 1999. 7 p. ilus, tab. Descriptors: ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS MAPEAMENTO DE EPITOPOS EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T ANTIGENOS HLA-DR ANTIGENO HLA-DR3 IMUNOFENOTIPAGEM HANSENIASE TRANSFORMAÇAO LINFOCITICA PESO MOLECULAR MYCOBACTERIUM LEPRAE LINFOCITOS T LINFOCITOS T Location: BR191.1; 07404/s

4 / 6

HANSEN

select to print

Id: 10291 Author: Rook, Graham A. W; Baker, Robert Title: Cortisol metabolism, cortisol sesitivity and the pathogenesis of leprosy reactions ..- Source: s.l; s.n; 1999. 6 p. ilus. Descriptors: CITOCINAS HIDROCORTISONA HIDROCORTISONA HIDROXIESTEROIDE DESIDROGENASES MACROFAGOS MACROFAGOS GRAVIDEZ COMPLICAÇOES INFECCIOSAS NA GRAVIDEZ COMPLICAÇOES INFECCIOSAS NA GRAVIDEZ PELE LINFOCITOS T LINFOCITOS T TUBERCULOSE Limits: ANIMAL Location: BR191.1; 07392/s

5 / 6

HANSEN

select to print

Id: 10264 Author: Mazumder, Shibnath; Nath, Indira; Dhar, M. M Title: Immunomodulation of human T cell responses with receptor selective enkephalins ..- Source: s.l; s.n; 1993. 6 p. graf. Descriptors: ADJUVANTES IMUNOLOGICOS SEQUENCIA DE AMINOACIDOS ENCEFALINA METIONINA ENCEFALINAS ENCEFALINAS IMUNOSSUPRESSORES HANSENIASE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PEPTIDIOS CICLICOS RECEPTORES OPIOIDES DELTA RECEPTORES OPIOIDES DELTA RECEPTORES OPIOIDES KAPPA RECEPTORES OPIOIDES MU RECEPTORES OPIOIDES MU FORMAÇAO DE ROSETA LINFOCITOS T LINFOCITOS T LINFOCITOS T TUBERCULOSE PULMONAR D-Penicilina (2,5)-Encefalina Limits: IN VITRO Location: BR191.1; 06943/s

6 / 6

HANSEN

select to print

Id: 10053 Author: Zea, Arnold H; Ochoa, Maria T; Ghosh, Paritosh; Longo, Dan L; Alvord, W. Gregory; Valderrama, Liliana; Falabella, Rafael; Harvey, Linda K; Saravia, Nancy; Moreno, Luis H; Ochoa, Augusto C Title: Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy ..- Source: s.l; s.n; 1998. 6 p. ilus, tab, graf. Descriptors: HANSENIASE CITOCINAS DNA NF-KAPPA B RECEPTORES DE ANTIGENO DA CÉLULA-T TRANSDUÇAO DE SINAL LINFOCITOS T Location: BR191.1; 07018/s

---

page 1 de 1

Refine the search

Database : HANSEN

Advanced form

Search for : Free form

		Search	in field
1			WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
2	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
3	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type

Search engine: iAH powered by WWWISIS

IAH - © BIREME/PAHO/WHO Latin American and Caribbean Center on Health Sciences Information